Details

Autor(en) / Beteiligte

• Saeed, Muhammad A
• Gribben, Kelli C
• Alam, Morshed
• Lyden, Elizabeth R
• Hanson, Corrine K
• LeVan, Tricia D

Titel

Association of Dietary Fiber on Asthma, Respiratory Symptoms and Inflammation in the Adult NHANES Population

Ist Teil von

• Annals of the American Thoracic Society, 2020-05

Ort / Verlag

United States

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• High intake of dietary fiber may have anti-inflammatory properties and be protective against respiratory morbidity. We examined the relationship between dietary fiber intake and asthma, respiratory symptoms and inflammation among adults who participated in the 2007-2012 National Health and Nutrition Examination Survey (NHANES). We analyzed data from adults 20-79 years of age (n=13,147) with complete information on fiber intake, total calorie intake, body mass index (BMI), smoking status and poverty level. Fiber intake was categorized into quartiles; Q1 being lowest quartile of intake and Q4 being highest quartile. Respiratory morbidities included asthma, wheeze, cough, and phlegm. Self-report questionnaires were used to define asthma, wheeze, cough and phlegm production. Serum C-reactive protein (CRP) was used as a biomarker of inflammation. Exclusion criteria included current pregnancy and implausible intake of total calories. 69.5% of participants were non-Hispanic white. 54.5% were non-smokers, and 7.8% had current asthma. After adjusting for co-variates, fiber intake was associated with asthma (p = 0.01), with an increased odds of asthma with lower fiber intake (Q1 vs. Q4, OR 1.4, 95% CI = 1.0-1.8, p = 0.027). There were significant interactions between fiber and sex and fiber and race/ethnicity; stronger associations were seen for women and for non-Hispanic white adults. Low fiber intake (Q1) was associated with an increased odds of wheeze (OR 1.3, 95% CI = 1.0-1.6; p = 0.018), cough (OR 1.7, 95% CI = 1.2-2.3; p = 0.002) and phlegm (OR 1.4, 95% CI = 1.1-2.0; p = 0.021) compared to high fiber intake. The odds of having high CRP versus non-detectable CRP were 1.6 times higher in the low fiber group (Q1) compared to high fiber group (Q4; OR 1.6, 95%CI = 1.0-2.5). High fiber diet may mediate an inflammatory response and decrease odds of having asthma especially for women and specific racial groups, cough, wheeze and phlegm production when compared with low fiber diet.