Details

Autor(en) / Beteiligte

• Al Saiegh, Fadi
• Ghosh, Ritam
• Leibold, Adam
• Avery, Michael B
• Schmidt, Richard F
• Theofanis, Thana
• Mouchtouris, Nikolaos
• Philipp, Lucas
• Peiper, Stephen C
• Wang, Zi-Xuan
• Rincon, Fred
• Tjoumakaris, Stavropoula I
• Jabbour, Pascal
• Rosenwasser, Robert H
• Gooch, M. Reid

Titel

Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke

Ist Teil von

• Journal of neurology, neurosurgery and psychiatry, 2020-08, Vol.91 (8), p.846-848

Ort / Verlag

England: BMJ Publishing Group LTD

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• BackgroundEmergence of the novel corona virus (severe acute respiratory syndrome (SARS)-CoV-2) in December 2019 has led to the COVID-19 pandemic. The extent of COVID-19 involvement in the central nervous system is not well established, and the presence or the absence of SARS-CoV-2 particles in the cerebrospinal fluid (CSF) is a topic of debate.Case descriptionWe present two patients with COVID-19 and concurrent neurological symptoms. Our first patient is a 31-year-old man who had flu-like symptoms due to COVID-19 and later developed an acute-onset severe headache and loss of consciousness and was diagnosed with a Hunt and Hess grade 3 subarachnoid haemorrhage from a ruptured aneurysm. Our second patient is a 62-year-old woman who had an ischaemic stroke with massive haemorrhagic conversion requiring a decompressive hemicraniectomy. Both patients’ CSF was repeatedly negative on real-time PCR analysis despite concurrent neurological disease.ConclusionOur report shows that patients’ CSF may be devoid of viral particles even when they test positive for COVID-19 on a nasal swab. Whether SARS-CoV-2 is present in CSF may depend on the systemic disease severity and the degree of the virus’ nervous tissue tropism and should be examined in future studies.