Zhongguo ying yong sheng li xue za zhi, 2019-11, Vol.35 (6), p.555
2019
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- Autor(en) / Beteiligte
- Titel
- Effects of oral exposure to zinc oxide nanoparticles on the peripheral organs of C57BL/6J mice
- Ist Teil von
- Zhongguo ying yong sheng li xue za zhi, 2019-11, Vol.35 (6), p.555
- Ort / Verlag
- China
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate the effects of oral exposure of zinc oxide nanoparticles on multiple peripheral organs of C57BL/6J mice. ;Methods: Twenty male C57BL/6J mice were randomly divided into control group and experimental group, with 10 mice in each group. The experimental group was treated with continuous gavage administration of zinc oxide nanoparticle solution at a dose of 20 mg/kg body weight for 60 days, and the control group was given the corresponding amount of normal saline; the mice were weighed once a week. After the end of the exposure, blood samples was collected from the eyeballs, and the levels of blood sugar and lipids, liver and kidney function, and inflammatory factors such as platelet activating factor (PAF), interleukin-6 (IL-6) and tumor septicemia (TNF-α) were detected. Then, tissues sections of the heart, liver, spleen, lung, kidney and small intestine were prepared and their morphological changes were observed after hematoxylin-eosin staining. ;Results: There was no significant difference in bo
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1000-6834DOI: 10.12047/j.cjap.5859.2019.122Titel-ID: cdi_pubmed_primary_32239865
- Format
- –
- Schlagworte
- Administration, Oral, Animals, Heart - drug effects, Intestine, Small - drug effects, Intestine, Small - pathology, Kidney - drug effects, Kidney - physiopathology, Liver - drug effects, Liver - physiopathology, Lung - drug effects, Lung - pathology, Male, Metal Nanoparticles - adverse effects, Mice, Mice, Inbred C57BL, Myocardium - pathology, Spleen - drug effects, Spleen - pathology, Toxicity Tests, Chronic, Zinc Oxide - adverse effects