Chemical communications (Cambridge, England), 2020-04, Vol.56 (33), p.467-461
2020
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- Autor(en) / Beteiligte
- Titel
- Sporormielones A-E, bioactive novel C-C coupled orsellinic acid derivative dimers, and their biosynthetic origin
- Ist Teil von
- Chemical communications (Cambridge, England), 2020-04, Vol.56 (33), p.467-461
- Ort / Verlag
- England: Royal Society of Chemistry
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Sporormielones A-E ( 1-5 ), novel C-C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were obtained, of which 1-3 and 5 showed obvious short-term memory improvement activity in AD flies. Based on transcriptome analysis, 13 C labelling, and gene deletion, their plausible biosynthetic mechanism was proposed. Sporormielones A-E, novel C-C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were isolated from Sporormiella sp., and their plausible biosynthetic mechanism was proposed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1359-7345eISSN: 1364-548XDOI: 10.1039/d0cc00855aTitel-ID: cdi_pubmed_primary_32211655
- Format
- –
- Schlagworte
- Abbreviations, Alzheimer Disease, Animals, Ascomycota - metabolism, Crystallography, Dimerization, Dimers, Diptera, Gene Expression Profiling, Memory, Short-Term - drug effects, Neuroprotective Agents - chemistry, Neuroprotective Agents - metabolism, Neuroprotective Agents - pharmacology, NMR, Nuclear magnetic resonance, Quantum chemistry, Resorcinols - chemistry, Resorcinols - metabolism, Resorcinols - pharmacology, Short term