Details

Autor(en) / Beteiligte

• Zhenhuan, Wu
• Yu, Dai
• Junsi, Luo
• Xiaowei, Ji
• Zongyu, Xie
• Li, Li
• Xiaoli, Xie

Titel

Physiochemical and biological evaluation of SLM-manufactured Ti-10Ta-2Nb-2Zr alloy for biomedical implant applications

Ist Teil von

• Biomedical materials (Bristol), 2020-07, Vol.15 (4), p.45017-045017

Ort / Verlag

England: IOP Publishing

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Titanium alloys, such as Ti-10Ta-2Nb-2Zr (TTNZ), are promising biomaterials due to their excellent biocompatibility and low Young's modulus. The TTNZ samples herein were manufactured by selective laser melting and the novel material was evaluated as a dental implant in vitro and in vivo. The microstructure, mechanical properties, electrochemical behaviour, cytotoxicity, haemocompatibility and osteogenic differentiation were systematically investigated. Based on the tensile test results, the as-printed TTNZ samples had an elongation of 20.23% ± 1.95%, an ultimate tensile strength of 646.61 ± 24.96 MPa and a Young's modulus of 23.72 ± 1.18 GPa. According to the biocompatible value, the as-printed TTNZ sample exhibited no cell cytotoxicity and it showed even better cell adhesion ability than that of the as-printed Ti-6Al-4 V and wrought Ti-6Al-4 V samples. The haemolysis percentage of the as-printed TTNZ sample was 0.629% ± 0.363%. Moreover, the as-printed TTNZ sample facilitated protein adsorption and osteogenic differentiation of human osteoblast-like (MG-63) cells in vitro. The in vivo data also demonstrated the histocompatibility of the as-printed TTNZ. In summary, the as-printed TTNZ developed in this study demonstrated good biocompatibility, low stress shielding, excellent ductility and great osteogenic differentiation. These results indicated that as-printed TTNZ alloys can be promising for end-use human biomedical applications.