Current topics in medicinal chemistry, 2020-01, Vol.20 (10), p.815-834
2020
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Details
- Autor(en) / Beteiligte
- Titel
- Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors
- Ist Teil von
- Current topics in medicinal chemistry, 2020-01, Vol.20 (10), p.815-834
- Ort / Verlag
- United Arab Emirates
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of EGFR inhibitors have been explored.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1568-0266eISSN: 1873-4294DOI: 10.2174/1568026620666200303123102Titel-ID: cdi_pubmed_primary_32124699
- Format
- –
- Schlagworte
- Animals, Antineoplastic Agents - chemistry, Antineoplastic Agents - pharmacology, Antineoplastic Agents, Immunological - chemistry, Antineoplastic Agents, Immunological - pharmacology, Apoptosis - drug effects, Cell Line, Tumor, Cell Proliferation - drug effects, Cytokines - metabolism, Drug Screening Assays, Antitumor, ErbB Receptors - antagonists & inhibitors, ErbB Receptors - genetics, ErbB Receptors - metabolism, Humans, Ligands, Models, Molecular, Mutation, Protein Binding, Protein Conformation, Protein Kinase Inhibitors - chemistry, Protein Kinase Inhibitors - pharmacology, Signal Transduction, Structure-Activity Relationship