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Autoantibodies against the prion protein in individuals with PRNP mutations
Ist Teil von
Neurology, 2020-10, Vol.95 (14), p.e2028
Ort / Verlag
United States
Erscheinungsjahr
2020
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
To determine whether naturally occurring autoantibodies against the prion protein are present in individuals with genetic prion disease mutations and controls, and if so, whether they are protective against prion disease.
In this case-control study, we collected 124 blood samples from individuals with a variety of pathogenic
mutations and 78 control individuals with a positive family history of genetic prion disease but lacking disease-associated
mutations. Antibody reactivity was measured using an indirect ELISA for the detection of human immunoglobulin G
antibodies against wild-type human prion protein. Multivariate linear regression models were constructed to analyze differences in autoantibody reactivity between (1)
mutation carriers vs controls and (2) asymptomatic vs symptomatic
mutation carriers. Robustness of results was examined in matched cohorts.
We found that antibody reactivity was present in a subset of both
mutation carriers and controls. Autoantibody levels were not influenced by
mutation status or clinical manifestation of prion disease. Post hoc analyses showed anti-PrP
autoantibody titers to be independent of personal history of autoimmune disease and other immunologic disorders, as well as
codon 129 polymorphism.
Pathogenic
variants do not notably stimulate antibody-mediated anti-PrP
immunity. Anti-PrP
immunoglobulin G autoantibodies are not associated with the onset of prion disease. The presence of anti-PrP
autoantibodies in the general population without any disease-specific association suggests that relatively high titers of naturally occurring antibodies are well-tolerated.
NCT02837705.