Zhōnghuá liúxíngbìng zázhì, 2019-12, Vol.40 (12), p.1629
2019
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- Autor(en) / Beteiligte
- Titel
- Characteristics and dynamics of HIV-1 subtype distribution among injected drug users in Guangzhou, 2008 - 2015
- Ist Teil von
- Zhōnghuá liúxíngbìng zázhì, 2019-12, Vol.40 (12), p.1629
- Ort / Verlag
- China
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To understand the characteristics and dynamics of individuals with HIV-1 subtype infection among injected drug users (HIV infection IDU) in Guangzhou between 2008 and 2015. HIV-1 RNAs were extracted from serum samples of the individuals that were newly diagnosed with HIV-1 infection among IDUs living in Guangzhou, between 2008 and 2015. The gene segments of HIV-1 genome from these RNA samples were amplified by nested reverse transcription polymerase chain reaction (Nested-PCR) and sequenced. Subsequently, phylogenetic tree was reconstructed using both sequences of samples and references before the subtype of HIV-1 was determined. Distributions of HIV-1 subtypes detected in IDUs with different demographic characteristics in different years were compared. A total of 437 gene segments were successfully obtained from 517 serum samples of HIV infection IDUs. The average age of 437 HIV infected IDUs was 37.37 years with standard deviation as 8.17 years. 51.5 (225/437) of the HIV infected IDU that registered residen
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 0254-6450DOI: 10.3760/cma.j.issn.0254-6450.2019.12.023Titel-ID: cdi_pubmed_primary_32062928
- Format
- –
- Schlagworte
- Adult, China, Drug Users, Genotype, HIV Infections - virology, HIV-1 - genetics, HIV-1 - isolation & purification, HIV-1 - pathogenicity, Humans, Phylogeny