Advances in experimental medicine and biology, 2020, Vol.1225, p.127-135
2020
Details
- Autor(en) / Beteiligte
- Titel
- Tumor Microenvironment Conditioning by Abortive Lytic Replication of Oncogenic γ-Herpesviruses
- Ist Teil von
- Advances in experimental medicine and biology, 2020, Vol.1225, p.127-135
- Ort / Verlag
- Switzerland: Springer International Publishing AG
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Epstein Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) constitute the human γ-herpesviruses and two of the seven human tumor viruses. In addition to their viral oncogenes that primarily belong to the latent infection programs of these viruses, they encode proteins that condition the microenvironment. Many of these are early lytic gene products and are only expressed in a subset of infected cells of the tumor mass. In this chapter I will describe their function and the evidence that targeting them in addition to the latent oncogenes could be beneficial for the treatment of EBV- and KSHV-associated malignancies.
- Sprache
- Englisch
- Identifikatoren
- ISBN: 3030357260, 9783030357269ISSN: 0065-2598eISSN: 2214-8019DOI: 10.1007/978-3-030-35727-6_9Titel-ID: cdi_pubmed_primary_32030652
- Format
- –
- Schlagworte
- Angiogenesis, Burkitt’s lymphoma, CCL5, Epstein Barr virus, Herpesvirus 4, Human - drug effects, Herpesvirus 4, Human - genetics, Herpesvirus 4, Human - growth & development, Herpesvirus 4, Human - pathogenicity, Herpesvirus 8, Human - drug effects, Herpesvirus 8, Human - genetics, Herpesvirus 8, Human - growth & development, Herpesvirus 8, Human - pathogenicity, Hodgkin’s lymphoma, Humans, Kaposi sarcoma, Kaposi sarcoma-associated herpesvirus, Lytic replication, Multicentric Castleman’s disease, Nasopharyngeal carcinoma, Neoplasms - drug therapy, Neoplasms - virology, Oncogenes - drug effects, Primary effusion lymphoma, Tumor Microenvironment, Viral IL-10, Viral IL-6, Viral MIP, Viral miRNA, Virus Replication - drug effects