Annual review of medicine, 2020-01, Vol.71 (1), p.263-276
2020
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- Autor(en) / Beteiligte
- Titel
- Hiding in Plain Sight: Interleukin-11 Emerges as a Master Regulator of Fibrosis, Tissue Integrity, and Stromal Inflammation
- Ist Teil von
- Annual review of medicine, 2020-01, Vol.71 (1), p.263-276
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Interleukin (IL)-11 is upregulated in a wide variety of fibro-inflammatory diseases such as systemic sclerosis, rheumatoid arthritis, pulmonary fibrosis, inflammatory bowel disease, kidney disease, drug-induced liver injury, and nonalcoholic steatohepatitis. IL-11 is a member of the IL-6 cytokine family and has several distinct properties that define its unique and nonredundant roles in disease. The IL-11 receptor is highly expressed on stromal, epithelial and polarized cells, where noncanonical IL-11 signaling drives the three pathologies common to all fibro-inflammatory diseases-myofibroblast activation, parenchymal cell dysfunction, and inflammation-while also inhibiting tissue regeneration. This cytokine has been little studied, and publications on IL-11 peaked in the early 1990s, when it was largely misunderstood. Here we describe recent advances in our understanding of IL-11 biology, outline how misconceptions as to its function came about, and highlight the large potential of therapies targeting IL-11 signaling for treating human disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0066-4219eISSN: 1545-326XDOI: 10.1146/annurev-med-041818-011649Titel-ID: cdi_pubmed_primary_31986085
- Format
- –
- Schlagworte
- Animals, Arthritis, Rheumatoid - immunology, Arthritis, Rheumatoid - metabolism, Arthritis, Rheumatoid - pathology, Chemical and Drug Induced Liver Injury - immunology, Chemical and Drug Induced Liver Injury - metabolism, Chemical and Drug Induced Liver Injury - pathology, Fibrosis - immunology, Fibrosis - metabolism, Fibrosis - pathology, Humans, Inflammation - immunology, Inflammation - metabolism, Inflammatory Bowel Diseases - immunology, Inflammatory Bowel Diseases - metabolism, Inflammatory Bowel Diseases - pathology, Interleukin-11 - immunology, Interleukin-11 - metabolism, Interleukin-11 - physiology, Interleukin-6 - immunology, Kidney Diseases - immunology, Kidney Diseases - metabolism, Kidney Diseases - pathology, Liver - immunology, Liver - metabolism, Liver - pathology, Lung - immunology, Lung - metabolism, Lung - pathology, Mice, Myofibroblasts - immunology, Myofibroblasts - metabolism, Myofibroblasts - pathology, Neoplasms - immunology, Neoplasms - metabolism, Non-alcoholic Fatty Liver Disease - immunology, Non-alcoholic Fatty Liver Disease - metabolism, Non-alcoholic Fatty Liver Disease - pathology, Pulmonary Fibrosis - immunology, Pulmonary Fibrosis - metabolism, Pulmonary Fibrosis - pathology, Recombinant Proteins, Scleroderma, Systemic - immunology, Scleroderma, Systemic - metabolism, Scleroderma, Systemic - pathology, Skin - immunology, Skin - metabolism, Skin - pathology