Details

Autor(en) / Beteiligte

• LIOTTI, F. S
• MENGHINI, A. R
• GUERRIERI, P
• MARIUCCI, G
• LOCCI, P
• BRUSCHELLI, G

Titel

Possible role of certain antioxidant enzymes in dimethylnitrosamine-induced liver carcinogenesis

Ist Teil von

• International journal of cancer, 1988-11, Vol.42 (5), p.803-806

Ort / Verlag

New York, NY: Wiley-Liss

Erscheinungsjahr

1988

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• An investigation was carried out to establish whether the reduction in catalase, glutathione peroxidase and superoxide dismutase activity, normally observed in liver tumours, is an early event and therefore of pathogenetic importance, or whether it is a late occurrence. Experiments performed on dimethylnitrosamine-treated hepatectomized and non-hepatectomized rats show that the decrease in activity of these enzymes is entirely due to hepatectomy, since the tumour-inducing doses of dimethylnitrosamine failed to provoke variations in the activity of these enzymes, in either normal or regenerating liver.