Details

Autor(en) / Beteiligte

• Wegener, Marius
• Müller-McNicoll, Michaela
• Oeffinger, Marlene
• Zenklusen, Daniel

Titel

View from an mRNP: The Roles of SR Proteins in Assembly, Maturation and Turnover

Ist Teil von

• Advances in experimental medicine and biology, 2019, Vol.1203, p.83-112

Ort / Verlag

Switzerland: Springer International Publishing AG

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Serine- and arginine-rich proteins (SR proteins) are a family of multitasking RNA-binding proteins (RBPs) that are key determinants of messenger ribonucleoprotein (mRNP) formation, identity and fate. Apart from their essential functions in pre-mRNA splicing, SR proteins display additional pre- and post-splicing activities and connect nuclear and cytoplasmic gene expression machineries. Through changes in their post-translational modifications (PTMs) and their subcellular localization, they provide functional specificity and adjustability to mRNPs. Transcriptome-wide UV crosslinking and immunoprecipitation (CLIP-Seq) studies revealed that individual SR proteins are present in distinct mRNPs and act in specific pairs to regulate different gene expression programmes. Adopting an mRNP-centric viewpoint, we discuss the roles of SR proteins in the assembly, maturation, quality control and turnover of mRNPs and describe the mechanisms by which they integrate external signals, coordinate their multiple tasks and couple subsequent mRNA processing steps.