Details

Autor(en) / Beteiligte

• Marković, Branislav M.
• Djurić, Veljko J.
• Lazarević, Mirjana
• Janković, Branislav D.

Titel

Anaphylactic shock-induced conditioned taste aversion: I. Demonstration of the phenomenon by means of three modes of CS-US presentation

Ist Teil von

• Brain, behavior, and immunity, 1988, Vol.2 (1), p.11-23

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

1988

Quelle

ScienceDirect

Beschreibungen/Notizen

• A series of three experiments was conducted to investigate whether an anaphylactic response could induce a conditioned modification of behavior. Rats sensitized to ovalbumin were subjected to a conditioning trial in which the conditioned stimulus (CS; saccharin solution) signaled the presentation of the unconditioned stimulus (US; shocking dose of ovalbumin), eliciting the unconditioned response (UR; anaphylactic shock). In a subsequent two-bottle preference test, immunized rats given a CS-US pairing developed a conditioned taste aversion toward an otherwise preferred saccharin solution. The phenomenon of anaphylactic shock-induced conditioned taste aversion was found to be robust and resistant to extinction during the 6-day test period and was established employing three modes of CS-US presentation: (a) CS po, US ip; (b) CS po, US iv; and (c) CS iv, US iv. The most effective mode of CS-US presentation for producing anaphylactic shock-induced taste aversion was observed in Experiment 1 (CS po, US ip). Thus, aversive manifestations of anaphylactic shock can serve as afferent signals by which the immune system informs the central nervous system which in turn modulates behavior.