Details

Autor(en) / Beteiligte

• Newtson, Andreea M
• Devor, Eric J
• Gonzalez Bosquet, Jesus

Titel

Prediction of Epithelial Ovarian Cancer Outcomes With Integration of Genomic Data

Ist Teil von

• Clinical obstetrics and gynecology, 2020-03, Vol.63 (1), p.92-108

Ort / Verlag

United States

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Some of the patients with epithelial ovarian cancer will not respond to initial therapy. These patients have a poor prognosis. Our aim was to identify patients with a worse prognosis by integrating clinical, pathologic, and genomic data. Using publicly available genomic data and integrating it with clinical data, we significantly improved the prediction of patients with worse surgical outcomes and those who do not respond to initial chemotherapy. We further improved these models with more precise data collection and better understanding of the genetic background of the studied population. Better prediction will lead to better patient classification and opportunities for individualized treatment.