Details

Autor(en) / Beteiligte

• Vatnehol, Svein Are Sirirud
• Hol, Per Kristian
• Bjørnerud, Atle
• Amiry-Moghaddam, Mahmood
• Haglerød, Camilla
• Storås, Tryggve Holck

Titel

Determination of oxygen r 1 at 3 Tesla using samples with a concentration range of dissolved oxygen

Ist Teil von

• Magma (New York, N.Y.), 2020-06, Vol.33 (3), p.447

Ort / Verlag

Germany

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• To investigate the sensitivity of modified Look-Locker inversion recovery (MOLLI) to measure changes in dissolved oxygen (DO) concentrations in water samples and to calculate sequence-specific relaxivity (r ) and limit of detection (LOD). Ten water samples with a range of DO concentrations were scanned at 3 T using two variations of MOLLI schemes. Using linear regression the r of DO was estimated from the measured DO concentrations and T relaxation rates (R ). The results were combined with previously reported values on in vivo stability measures of the MOLLI sequences and used to estimate a LOD. DO concentrations ranged from 0.5 to 21.6 mg L . A linear correlation between DO and R was obtained with both MOLLI sequences, with an average correlation coefficient (R ) 0.9 and an average estimated r ([Formula: see text]) of 4.45 × 10  s  mg  L. Estimated LOD was ≈ 10 mg L . MOLLI T -mapping sequences may be used for detecting dissolved oxygen in vivo at 3 T with an [Formula: see text] in the range 4.18-4.8 × 10  s  mg  L and a corresponding LOD for dissolved oxygen of approximately 10 mg L . MOLLI-based T mapping may be a useful non-invasive tool for quantification of in vivo changes of DO concentration during oxygen challenges.