Details

Autor(en) / Beteiligte

• Park, S
• Yang, B R
• Song, H J
• Jang, S H
• Kang, D Y
• Park, B-J

Titel

Metformin and tuberculosis risk in elderly patients with diabetes mellitus

Ist Teil von

• The international journal of tuberculosis and lung disease, 2019-08, Vol.23 (8), p.924-930

Ort / Verlag

France

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Tuberculosis (TB) and diabetes mellitus (DM) remain global health concerns. Metformin has recently received attention for its anti-tuberculosis effects. To evaluate the risk of TB development in elderly DM patients treated with metformin compared with sulfonylureas. We performed a retrospective cohort study using the National Health Insurance Service-Senior database. The participants were type-2 DM (T2DM) patients aged ≥60 years between 1 January 2003 and 31 December 2013. We matched each metformin user to a sulfonylurea user using a propensity score. A Cox proportional hazards model was used to compare the risk of TB in metformin and sulfonylurea users. After propensity score matching, 12,582 patients were in each group. The TB incidence was 280.2/100 000 person-years (py) for metformin users and 394.5/100 000 py for sulfonylurea users. Metformin users had a lower risk of TB development than sulfonylurea users (adjusted hazard ratio 0.74, 95%CI 0.58-0.95), and the results were stronger for male participants. A dose-response relationship between metformin use and TB development was found in both sexes. Metformin use was associated with a decreased risk of TB development among elderly T2DM patients compared with sulfonylurea use.