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Effector T H 17 Cells Give Rise to Long-Lived T RM Cells that Are Essential for an Immediate Response against Bacterial Infection
Ist Teil von
Cell, 2019-08, Vol.178 (5), p.1176
Ort / Verlag
United States
Erscheinungsjahr
2019
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Adaptive immunity provides life-long protection by generating central and effector memory T cells and the most recently described tissue resident memory T (T
) cells. However, the cellular origin of CD4 T
cells and their contribution to host defense remain elusive. Using IL-17A tracking-fate mouse models, we found that a significant fraction of lung CD4 T
cells derive from IL-17A-producing effector (T
17) cells following immunization with heat-killed Klebsiella pneumonia (Kp). These exT
17 T
cells are maintained in the lung by IL-7, produced by lymphatic endothelial cells. During a memory response, neither antibodies, γδ T cells, nor circulatory T cells are sufficient for the rapid host defense required to eliminate Kp. Conversely, using parabiosis and depletion studies, we demonstrated that exT
17 T
cells play an important role in bacterial clearance. Thus, we delineate the origin and function of airway CD4 T
cells during bacterial infection, offering novel strategies for targeted vaccine design.