Details

Autor(en) / Beteiligte

• Shapey, Jonathan
• Toma, A
• Saeed, S R

Titel

Physiology of cerebrospinal fluid circulation

Ist Teil von

• Current opinion in otolaryngology & head and neck surgery, 2019-10, Vol.27 (5), p.326-333

Ort / Verlag

United States

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• This article describes the physiology of cerebrospinal fluid (CSF). We review current evidence and new concepts relating to CSF physiology with respect to CSF secretion, circulation and resorption and we highlight key pathophysiological associations including the relationship between CSF and intracranial pressure. CSF secretion occurs primarily via the choroid plexus. Various transport mechanisms facilitate CSF secretion but the role Aquaporins play in this process is a recent discovery and an area of ongoing research. CSF circulation is a dynamic process but the importance of the perivascular 'Glymphatic system' and extraarachnoidal pathways of resorption are relatively new concepts. CSF physiology is dependent on various interacting factors and is critical for normal brain development and function.