Details

Autor(en) / Beteiligte

• Weizman, Orr-El
• Song, Eric
• Adams, Nicholas M
• Hildreth, Andrew D
• Riggan, Luke
• Krishna, Chirag
• Aguilar, Oscar A
• Leslie, Christina S
• Carlyle, James R
• Sun, Joseph C
• O'Sullivan, Timothy E

Titel

Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12

Ist Teil von

• Nature immunology, 2019-08, Vol.20 (8), p.1004-1011

Ort / Verlag

United States

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Innate lymphoid cells (ILCs) are tissue-resident sentinels that are essential for early host protection from pathogens at initial sites of infection. However, whether pathogen-derived antigens directly modulate the responses of tissue-resident ILCs has remained unclear. In the present study, it was found that liver-resident type 1 ILCs (ILC1s) expanded locally and persisted after the resolution of infection with mouse cytomegalovirus (MCMV). ILC1s acquired stable transcriptional, epigenetic and phenotypic changes a month after the resolution of MCMV infection, and showed an enhanced protective effector response to secondary challenge with MCMV consistent with a memory lymphocyte response. Memory ILC1 responses were dependent on the MCMV-encoded glycoprotein m12, and were independent of bystander activation by proinflammatory cytokines after heterologous infection. Thus, liver ILC1s acquire adaptive features in an MCMV-specific manner.