Nature reviews. Genetics, 2019-07, Vol.20 (7), p.417-431
2019
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Regulation of transposable elements by DNA modifications
- Ist Teil von
- Nature reviews. Genetics, 2019-07, Vol.20 (7), p.417-431
- Ort / Verlag
- England
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Maintenance of genome stability requires control over the expression of transposable elements (TEs), whose activity can have substantial deleterious effects on the host. Chemical modification of DNA is a commonly used strategy to achieve this, and it has long been argued that the emergence of 5-methylcytosine (5mC) in many species was driven by the requirement to silence TEs. Potential roles in TE regulation have also been suggested for other DNA modifications, such as N6-methyladenine and oxidation derivatives of 5mC, although the underlying mechanistic relationships are poorly understood. Here, we discuss current evidence implicating DNA modifications and DNA-modifying enzymes in TE regulation across different species.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-0056eISSN: 1471-0064DOI: 10.1038/s41576-019-0106-6Titel-ID: cdi_pubmed_primary_30867571
- Format
- –
- Schlagworte
- 5-Methylcytosine - metabolism, Adenosine - analogs & derivatives, Adenosine - metabolism, Animals, Biological Evolution, DNA (Cytosine-5-)-Methyltransferases - genetics, DNA (Cytosine-5-)-Methyltransferases - metabolism, DNA Methylation, DNA Transposable Elements, Epigenesis, Genetic, Gene Transfer, Horizontal, Genetic Drift, Humans, Plants - genetics, Plants - metabolism, RNA, Small Interfering - genetics, RNA, Small Interfering - metabolism