Details

Autor(en) / Beteiligte

• Liu, S
• Huang, L P
• Lin, Z
• Liu, Y F
• Zheng, Z R
• Peng, X E
• Chen, W L
• Hu, Z J

Titel

Association between the time of neutrophils to the lowest and prognosis of patients with esophageal squamous cell carcinoma treated with non-operative therapy

Ist Teil von

• Zhōnghuá zhŏngliú zázhì, 2019-02, Vol.41 (2), p.124

Ort / Verlag

China

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• To investigate the association between the time of neutrophils to the lowest and prognosis of patients with esophageal squamous cell carcinoma (ESCC) treated with non-operative therapy. The clinical data of 325 non-operative treated ESCC patients were collected in this study. The X-title software was applied to establish optimal threshold of neutrophil reduction to the lowest value. According to the optimal threshold, the patients were divided into early group (115 cases) and late group (210 cases). The clinical features and survival time of the two groups were compared, and the factors of prognosis were analyzed by Cox regression model with univariate and multivariate analysis. The X-title software demonstrated the optimal cutoff values for the time of neutrophils to the lowest was 39 days. The median overall survival time was 21.0 months in the early group which was significantly higher than that in the late group (16.0 months). Multivariate Cox regression analysis showed that the treatment methods and the