Details

Autor(en) / Beteiligte

• Ravetch, Jeffrey V
• Nimmerjahn, Falk

Titel

IgG Fc Glycosylation in Human Immunity

Ist Teil von

• Current topics in microbiology and immunology, 2019, Vol.423, p.63-75

Ort / Verlag

Switzerland: Springer International Publishing AG

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Glycosylation of IgG Fc domains is a central mechanism in the diversification of antibody function. Modifications to the core Fc glycan impact antibody function by shifting the balance of Type I and Type II Fc gamma receptors (FcγR) that will be engaged by immune complexes. This, in turn, modulates the effector cells and functions that can be recruited during immune activation. Critically, humans have evolved to regulate Fc glycan modifications for immune homeostasis. Dysregulation in Fc glycan modifications can lead to loss of immune tolerance, symptomatic autoimmunity, and susceptibility to infectious diseases. Here, we discuss IgG Fc glycosylation and its role in human health and disease.