Details

Autor(en) / Beteiligte

• Shen, Xue-Ning
• Miao, Dan
• Li, Jie-Qiong
• Tan, Chen-Chen
• Cao, Xi-Peng
• Tan, Lan
• Yu, Jin-Tai

Titel

MAPT rs242557 variant is associated with hippocampus tau uptake on 18 F-AV-1451 PET in non-demented elders

Ist Teil von

• Aging (Albany, NY.), 2019-01, Vol.11 (3), p.874

Ort / Verlag

United States

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• The microtubule-associated protein tau gene ( ) rs242557 variant is associated with multiple tauopathies and dementia. This study investigated whether it was correlated with brain tau-PET uptake in non-demented elders. Ninety non-demented elders were identified from the Alzheimer's Disease Neuroimaging Initiative cohort. We compared standardized uptake value ratios (SUVRs) of tau-PET tracer F-AV-1451 between rs242557 variant carriers and non-carriers in 25 regions of interest (ROIs). The minor allele A was associated with increased hippocampus F-AV-1451 uptake in non-demented elders (left: β = 0.111, Bonferroni corrected p = 0.035; right: β = 0.103, Bonferroni corrected p = 0.031). Aβ-positive participants (left: β = 0.206, Bonferroni corrected p = 0.029; right: β = 0.198, Bonferroni corrected p = 0.035) and 4 non-carriers (left: β = 0.140, Bonferroni corrected p = 0.006; right: β = 0.134, Bonferroni corrected p = 0.004) exhibited approximately the same findings in hippocampus. Considering no obvious associations in other regions, we confirmed the significant correlation of rs242557 risk variant with increased hippocampus tau deposition in non-demented elders. With higher magnitude signals in the hippocampus that is more likely to be uniquely affected in AD, the tau PET ligand F-AV-1451 seemed to possess a specific binding property for AD-like tau pathology.