Details

Autor(en) / Beteiligte

• Abdelmoniem, Amr M
• Mohamed, Magda F
• Abdelmoniem, Doaa M
• Ghozlan, Said A S
• Abdelhamid, Ismail A

Titel

Recent Synthetic Approaches and Biological Evaluations of Amino Hexahydroquinolines and Their Spirocyclic Structures

Ist Teil von

• Anti-cancer agents in medicinal chemistry, 2019-01, Vol.19 (7), p.875-915

Ort / Verlag

Netherlands

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• In this review, the recent synthetic approaches of amino hexahydroquinolines and their spirocyclic structures were highlighted. The synthetic routes include, two-components, three-components or fourcomponents reactions. The two-component [3+3] atom combination reaction represents the simplest method. It involves Michael addition of the electron rich β-carbon of β-enaminones to the activated double bond of cinnamonitriles followed by cyclization to yield hexahydroquinoline compounds. The bioactivity profiles and SAR studies of these compounds were also reviewed with emphasis to the utility of these substances as antimicrobial, anticancer and antitubercular agents, as well as calcium channel modulators.