Details

Autor(en) / Beteiligte

• Tan, Eugene S J
• Tay, Wan Ting
• Teng, Tiew-Hwa Katherine
• Sim, David
• Leong, Kui Toh Gerard
• Yeo, Poh Shuan Daniel
• Ong, Hean Yee
• Jaufeerally, Fazlur
• Ng, Tze Pin
• Poppe, Katrina
• Lund, Mayanna
• Devlin, Gerard
• Troughton, Richard W
• Ling, Lieng Hsi
• Richards, Arthur Mark
• Doughty, Robert N
• Lam, Carolyn S P

Titel

Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific

Ist Teil von

• Heart (British Cardiac Society), 2019-06, Vol.105 (11), p.842-847

Ort / Verlag

England: BMJ Publishing Group LTD

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• ObjectiveEthnic differences in the prevalence of atrial fibrillation (AF) in heart failure (HF) remain unclear. We compared the prevalence and clinical correlates of AF among different ethnicities in an Asian-Pacific population with HF.MethodsPatients with validated HF were prospectively studied across Singapore and New Zealand (NZ).ResultsAmong 1746 patients with HF (62% Asian, 26% women, mean age 66 (SD 13) years, mean ejection fraction (EF) 37 (SD 16%), 39% had AF. The prevalence of AF was markedly lower in Singapore-Asians than NZ-Europeans (24% vs 63%; p<0.001), even after adjusting for age, clinical and echocardiographic covariates, regardless of EF group (pinteraction for EF=0.39). Patients with AF were older, had higher body mass index and were more likely to have a history of hypertension, stroke, peripheral vascular disease, renal disease, chronic respiratory disease and increased alcohol intake, but less likely to have diabetes. Clinical correlates were similar for Asians and NZ-Europeans, except diabetes: Asian diabetic patients with HF had less AF compared with Asian patients without diabetes (OR 0.66, 95% CI 0.50 to 0.88), whereas among NZ-Europeans there was no significant association between diabetes and AF (OR 1.22, 95% CI 0.85 to 1.75) (pinteraction for ethnicity=0.01). AF was associated with a higher crude composite outcome of mortality and HF hospitalisations at 2 years (HR 1.19, 95% CI 1.02 to 1.38).ConclusionThere is a strikingly lower prevalence of AF among Asian compared with NZ-European patients with HF. The underlying mechanisms for the lower prevalence of AF among Asians, particularly in the presence of diabetes, deserve further study.Trial registration numberACTRN12610000374066.