Details

Autor(en) / Beteiligte

• Sami, Sarmed S
• Ravindran, Adharsh
• Kahn, Allon
• Snyder, Diana
• Santiago, Jose
• Ortiz-Fernandez-Sordo, Jacobo
• Tan, Wei Keith
• Dierkhising, Ross A
• Crook, Julia E
• Heckman, Michael G
• Johnson, Michele L
• Lansing, Ramona
• Ragunath, Krish
• di Pietro, Massimiliano
• Wolfsen, Herbert
• Ramirez, Francisco
• Fleischer, David
• Wang, Kenneth K
• Leggett, Cadman L
• Katzka, David A
• Iyer, Prasad G

Titel

Timeline and location of recurrence following successful ablation in Barrett’s oesophagus: an international multicentre study

Ist Teil von

• Gut, 2019-08, Vol.68 (8), p.1379-1385

Erscheinungsjahr

2019

Beschreibungen/Notizen

• Objective Surveillance interval protocols after complete remission of intestinal metaplasia (CRIM) post radiofrequency ablation (RFA) in Barrett’s oesophagus (BE) are currently empiric and not based on substantial evidence. We aimed to assess the timeline, location and patterns of recurrence following CRIM to inform these guidelines. Design Data on patients undergoing RFA for BE were obtained from prospectively maintained databases of five (three USA and two UK) tertiary referral centres. RFA was performed until CRIM was confirmed on two consecutive endoscopies. Results 594 patients achieved CRIM as of 1 May 2017. 151 subjects developed recurrent BE over a median (IQR) follow-up of 2.8 (1.4–4.4) years. There was 19% cumulative recurrence risk of any BE within 2 years and an additional 49% risk over the next 8.6 years. There was no evidence of a clinically meaningful change in the recurrence hazard rate of any BE, dysplastic BE or high-grade dysplasia/cancer over the duration of follow-up, with an estimated 2% (95% CI −7% to 12%) change in recurrence rate of any BE in a doubling of follow-up time. 74% of BE recurrences developed at the gastro-oesophageal junction (GOJ) (24.1% were dysplastic) and 26% in the tubular oesophagus. The yield of random biopsies from the tubular oesophagus, in the absence of visible lesions, was 1% (BE) and 0.2% (dysplasia). Conclusions BE recurrence risk following CRIM remained constant over time, suggesting that lengthening of follow-up intervals, at least in the first 5 years after CRIM, may not be advisable. Sampling the GOJ is critical to detecting recurrence. The requirement for random biopsies of the neosquamous epithelium in the absence of visible lesions may need to be re-evaluated.