Nucleic acids research, 2019-02, Vol.47 (4), p.1786-1796
2019
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Details
- Autor(en) / Beteiligte
- Titel
- Differential regulation of RNA polymerase III genes during liver regeneration
- Ist Teil von
- Nucleic acids research, 2019-02, Vol.47 (4), p.1786-1796
- Ort / Verlag
- England
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Mouse liver regeneration after partial hepatectomy involves cells in the remaining tissue synchronously entering the cell division cycle. We have used this system and H3K4me3, Pol II and Pol III profiling to characterize adaptations in Pol III transcription. Our results broadly define a class of genes close to H3K4me3 and Pol II peaks, whose Pol III occupancy is high and stable, and another class, distant from Pol II peaks, whose Pol III occupancy strongly increases after partial hepatectomy. Pol III regulation in the liver thus entails both highly expressed housekeeping genes and genes whose expression can adapt to increased demand.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0305-1048eISSN: 1362-4962DOI: 10.1093/nar/gky1282Titel-ID: cdi_pubmed_primary_30597109
- Format
- –
- Schlagworte
- Animals, Cell Cycle - genetics, Cell Division - genetics, Chromatin Immunoprecipitation, Gene Expression Regulation, Developmental - genetics, Hepatectomy, Histone-Lysine N-Methyltransferase - chemistry, Histone-Lysine N-Methyltransferase - genetics, Histones - chemistry, Histones - genetics, Humans, Liver - growth & development, Liver - pathology, Liver - surgery, Liver Regeneration - genetics, Mice, Protein Binding, RNA Polymerase II - chemistry, RNA Polymerase II - genetics, RNA Polymerase III - chemistry, RNA Polymerase III - genetics, Transcription, Genetic