Journal of Alzheimer's disease, 2019-01, Vol.67 (2), p.481-488
2019
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Details
- Autor(en) / Beteiligte
- Titel
- Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment
- Ist Teil von
- Journal of Alzheimer's disease, 2019-01, Vol.67 (2), p.481-488
- Ort / Verlag
- Netherlands
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Reliable blood biomarkers for Alzheimer's disease (AD) are missing. We measured astroglial GFAP in patients with AD (n = 28), frontotemporal dementia (bvFTD, n = 35), Parkinson's disease (n = 11), Lewy body dementias (n = 19), and controls (n = 34). Serum GFAP was increased in AD (p < 0.001) and DLB/PDD (p < 0.01), and cerebrospinal fluid GFAP was increased in all neurodegenerative diseases (p < 0.001). Serum GFAP correlated with the Mini-Mental State Examination score (r= -0.42, p < 0.001) and might be a follow-up marker in clinical trials. Sensitivity and specificity of serum GFAP for AD versus bvFTD was 89% and 79% and might be the first blood biomarker in the differential diagnosis of AD and bvFTD.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1387-2877eISSN: 1875-8908DOI: 10.3233/JAD-180325Titel-ID: cdi_pubmed_primary_30594925
- Format
- –
- Schlagworte
- Aged, Alzheimer Disease - blood, Alzheimer Disease - psychology, Biomarkers - blood, Cognitive Dysfunction - psychology, Diagnosis, Differential, Female, Frontotemporal Dementia - blood, Frontotemporal Dementia - cerebrospinal fluid, Frontotemporal Dementia - psychology, Glial Fibrillary Acidic Protein - blood, Glial Fibrillary Acidic Protein - cerebrospinal fluid, Humans, Lewy Body Disease - blood, Lewy Body Disease - cerebrospinal fluid, Lewy Body Disease - psychology, Male, Mental Status and Dementia Tests, Middle Aged, Parkinson Disease - blood, Parkinson Disease - cerebrospinal fluid, Parkinson Disease - psychology, Pilot Projects, Sensitivity and Specificity