Journal of pediatric hematology/oncology, 2020-01, Vol.42 (1), p.e61-e63
2020
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Details
- Autor(en) / Beteiligte
- Titel
- Burkitt Leukemia With Precursor B-Cell Immunophenotype and Dual Translocation of t(14;18) and t(8;14) in a Child: Case Report and Review of the Literature
- Ist Teil von
- Journal of pediatric hematology/oncology, 2020-01, Vol.42 (1), p.e61-e63
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Burkitt leukemia (BL) with the precursor B-cell immunophenotype is a rarely reported condition. The prognosis of such patients is similar to that of classic BL. However, the combination of chromosomal translocations associated with bcl-2 and c-myc rearrangement has a poor prognosis. An 11-year-old child presented with fever and weakness. Bone marrow aspiration showed morphologically L1 type blasts and flow cytometry analysis was compatible with precursor B-cell immunophenotype. Cytogenetic analysis revealed a combination of t(8;14) and t(14;l8). The combination of t(8;14) and t(14;l8) can exhibit different immunophenotypical and morphologic features in leukemias.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1077-4114eISSN: 1536-3678DOI: 10.1097/MPH.0000000000001354Titel-ID: cdi_pubmed_primary_30499905
- Format
- –
- Schlagworte
- Burkitt Lymphoma - blood, Burkitt Lymphoma - genetics, Burkitt Lymphoma - immunology, Burkitt Lymphoma - pathology, Child, Chromosomes, Human - genetics, Cytogenetic Analysis, Flow Cytometry, Humans, Immunophenotyping, Male, Precursor Cells, B-Lymphoid - immunology, Precursor Cells, B-Lymphoid - metabolism, Precursor Cells, B-Lymphoid - pathology, Proto-Oncogene Proteins c-bcl-2 - genetics, Proto-Oncogene Proteins c-bcl-2 - immunology, Proto-Oncogene Proteins c-myc - genetics, Proto-Oncogene Proteins c-myc - immunology, Translocation, Genetic