Details

Autor(en) / Beteiligte

• Almeda-Valdes, Paloma
• Gómez Velasco, Donaji V
• Arellano Campos, Olimpia
• Bello-Chavolla, Omar Yaxmehen
• Del Rocío Sevilla-González, Magdalena
• Viveros Ruiz, Tannia
• Martagón Rosado, Alexandro J
• Bautista, Claudia J
• Muñoz Hernandez, Liliana
• Cruz-Bautista, Ivette
• Moreno-Macias, Hortensia
• Huerta-Chagoya, Alicia
• Rodríguez-Álvarez, Karen Guadalupe
• Walford, Geoffrey A
• Jacobs, Suzanne B R
• Guillen Pineda, Luz E
• Ordoñez-Sánchez, Ma Luisa
• Roldan-Valadez, Ernesto
• Azpiroz, Joaquín
• Furuzawa-Carballeda, Jannette
• Clark, Patricia
• Herrera-Hernández, Miguel F
• Zambrano, Elena
• Florez, Jose C
• Tusié Luna, María Teresa
• Aguilar-Salinas, Carlos A

Titel

The SLC16A11 risk haplotype is associated with decreased insulin action, higher transaminases and large-size adipocytes

Ist Teil von

• European journal of endocrinology, 2019-02, Vol.180 (2), p.99

Ort / Verlag

England

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective A haplotype at chromosome 17p13 that reduces expression and function of the solute carrier transporter SLC16A11 is associated with increased risk for type 2 diabetes in Mexicans. We aim to investigate the detailed metabolic profile of SLC16A11 risk haplotype carriers to identify potential physiological mechanisms explaining the increased type 2 diabetes risk. Design Cross-sectional study. Methods We evaluated carriers (n = 72) and non-carriers (n = 75) of the SLC16A11 risk haplotype, with or without type 2 diabetes. An independent sample of 1069 subjects was used to replicate biochemical findings. The evaluation included euglycemic-hyperinsulinemic clamp, frequently sampled intravenous glucose tolerance test (FSIVGTT), dual-energy X-ray absorptiometry (DXA), MRI and spectroscopy and subcutaneous abdominal adipose tissue biopsies. Results Fat-free mass (FFM)-adjusted M value was lower in carriers of the SLC16A11 risk haplotype after adjusting for age and type 2 diabetes status (β = -0.164, P = 0.04). Subjects with type 2 diabetes and the risk haplotype demonstrated an increase of 8.76 U/L in alanine aminotransferase (ALT) (P = 0.02) and of 7.34 U/L in gamma-glutamyltransferase (GGT) (P = 0.05) compared with non-carriers and after adjusting for gender, age and ancestry. Among women with the risk haplotype and normal BMI, the adipocyte size was higher (P < 0.001). Conclusions Individuals carrying the SLC16A11 risk haplotype exhibited decreased insulin action. Higher serum ALT and GGT levels were found in carriers with type 2 diabetes, and larger adipocytes in subcutaneous fat in the size distribution in carrier women with normal weight.