Details

Autor(en) / Beteiligte

• Clemens, J D
• Sack, D A
• Harris, J R
• Chakraborty, J
• Neogy, P K
• Stanton, B
• Huda, N
• Khan, M U
• Kay, B A
• Khan, M R

Titel

Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli: results of a large-scale field trial

Ist Teil von

• The Journal of infectious diseases, 1988-08, Vol.158 (2), p.372

Ort / Verlag

United States

Erscheinungsjahr

1988

Quelle

MEDLINE

Beschreibungen/Notizen

• The B subunit (BS) of cholera toxin and that of the heat-labile enterotoxin (LT) of enterotoxigenic Escherichia coli (ETEC) are antigenically similar. We therefore assessed whether a combined cholera toxin BS/whole-cell (BS-WC) oral vaccine against cholera conferred cross-protection against LT-producing ETEC (LT-ETEC) diarrhea in a randomized, double-blind field trial among rural Bangladeshi children and women. The 24,770 persons who ingested two or more doses of BS-WC vaccine were compared with 24,842 controls who took two or more doses of killed whole-cell (WC) oral cholera vaccine. Sixty-seven percent fewer episodes of LT-ETEC diarrhea were noted in the BS-WC group than in the WC group during short-term (three-month) follow-up (P less than .01), but no reduction was evident during the ensuing nine months. Short-term protection was particularly notable against LT-ETEC diarrhea causing life-threatening dehydration (protective efficacy, 86%; P less than .05).