Details

Autor(en) / Beteiligte

• O'Leary, Claire E
• Schneider, Christoph
• Locksley, Richard M

Titel

Tuft Cells-Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry

Ist Teil von

• Annual review of immunology, 2019-04, Vol.37 (1), p.47-72

Ort / Verlag

United States

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Tuft cells-rare solitary chemosensory cells in mucosal epithelia-are undergoing intense scientific scrutiny fueled by recent discovery of unsuspected connections to type 2 immunity. These cells constitute a conduit by which ligands from the external space are sensed via taste-like signaling pathways to generate outputs unique among epithelial cells: the cytokine IL-25, eicosanoids associated with allergic immunity, and the neurotransmitter acetylcholine. The classic type II taste cell transcription factor POU2F3 is lineage defining, suggesting a conceptualization of these cells as widely distributed environmental sensors with effector functions interfacing type 2 immunity and neural circuits. Increasingly refined single-cell analytics have revealed diversity among tuft cells that extends from nasal epithelia and type II taste cells to ex- -expressing medullary thymic cells and small-intestine cells that mediate tissue remodeling in response to colonizing helminths and protists.