Details

Autor(en) / Beteiligte

• Xiao, Fu-Hui
• Chen, Xiao-Qiong
• Yu, Qin
• Ye, Yunshuang
• Liu, Yao-Wen
• Yan, Dongjing
• Yang, Li-Qin
• Chen, Guijun
• Lin, Rong
• Yang, Liping
• Liao, Xiaoping
• Zhang, Wen
• Zhang, Wei
• Tang, Nelson Leung-Sang
• Wang, Xiao-Fan
• Zhou, Jumin
• Cai, Wang-Wei
• He, Yong-Han
• Kong, Qing-Peng

Titel

Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians

Ist Teil von

• Genome research, 2018-11, Vol.28 (11), p.1601-1610

Ort / Verlag

United States

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Centenarians (CENs) are excellent subjects to study the mechanisms of human longevity and healthy aging. Here, we analyzed the transcriptomes of 76 centenarians, 54 centenarian-children, and 41 spouses of centenarian-children by RNA sequencing and found that, among the significantly differentially expressed genes (SDEGs) exhibited by CENs, the autophagy-lysosomal pathway is significantly up-regulated. Overexpression of several genes from this pathway, , , , and , could promote autophagy and delay senescence in cultured IMR-90 cells, while overexpression of the homolog of , , extended the life span in transgenic flies. Interestingly, the enhanced autophagy-lysosomal activity could be partially passed on to their offspring, as manifested by their higher levels of both autophagy-encoding genes and serum beclin 1 (BECN1). In light of the normal age-related decline of autophagy-lysosomal functions, these findings provide a compelling explanation for achieving longevity in, at least, female CENs, given the gender bias in our collected samples, and suggest that the enhanced waste-cleaning activity via autophagy may serve as a conserved mechanism to prolong the life span from to humans.