Pediatric neurosurgery, 2018-01, Vol.53 (5), p.311-316
2018
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- Autor(en) / Beteiligte
- Titel
- Synchronous Primary Central Nervous System and Pulmonary Lymphoma in a 7-Year-Old Female with Unspecified T-Cell Immunodeficiency
- Ist Teil von
- Pediatric neurosurgery, 2018-01, Vol.53 (5), p.311-316
- Ort / Verlag
- Basel, Switzerland
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Primary central nervous system lymphoma (PCNSL) is rare in children with immunocompromise as an important risk factor. A 7-year-old girl with unspecified T-cell immunodeficiency presented with left-sided weakness and was found to have a right-sided frontal lobe mass on imaging. The mass was resected; histopathology and molecular studies evidenced diffuse large B-cell lymphoma. Prior chest imaging had revealed left upper lobe mass, and repeat chest imaging revealed multiple pulmonary nodules, initially concerning for metastasis. Video-assisted thoracoscopic surgical wedge resection of the lung mass was performed; the molecular profile was distinct from the PCNSL, suggesting synchronous de novo lymphomagenesis of brain and pulmonary primaries.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1016-2291eISSN: 1423-0305DOI: 10.1159/000490728Titel-ID: cdi_pubmed_primary_30110687
- Format
- –
- Schlagworte
- Central Nervous System Neoplasms - diagnostic imaging, Central Nervous System Neoplasms - pathology, Central Nervous System Neoplasms - surgery, Child, Diagnosis, Differential, Female, Frontal Lobe, Humans, Lung Neoplasms - diagnostic imaging, Lung Neoplasms - pathology, Lung Neoplasms - surgery, Lymphoma, Large B-Cell, Diffuse - diagnostic imaging, Lymphoma, Large B-Cell, Diffuse - pathology, Lymphoma, Large B-Cell, Diffuse - surgery, Magnetic Resonance Imaging, Neoplasms, Multiple Primary - diagnostic imaging, Neoplasms, Multiple Primary - pathology, Neoplasms, Multiple Primary - surgery, Original Paper, Thoracic Surgery, Video-Assisted - methods