Details

Autor(en) / Beteiligte

• Troeger, Christopher
• Khalil, Ibrahim A
• Rao, Puja C
• Cao, Shujin
• Blacker, Brigette F
• Ahmed, Tahmeed
• Armah, George
• Bines, Julie E
• Brewer, Thomas G
• Colombara, Danny V
• Kang, Gagandeep
• Kirkpatrick, Beth D
• Kirkwood, Carl D
• Mwenda, Jason M
• Parashar, Umesh D
• Petri, Jr, William A
• Riddle, Mark S
• Steele, A Duncan
• Thompson, Robert L
• Walson, Judd L
• Sanders, John W
• Mokdad, Ali H
• Murray, Christopher J L
• Hay, Simon I
• Reiner, Jr, Robert C

Titel

Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years

Ist Teil von

• JAMA pediatrics, 2018-10, Vol.172 (10), p.958

Ort / Verlag

United States

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Rotavirus infection is the global leading cause of diarrhea-associated morbidity and mortality among children younger than 5 years. To examine the extent of rotavirus infection among children younger than 5 years by country and the number of deaths averted because of the rotavirus vaccine. This report builds on findings from the Global Burden of Disease Study 2016, a cross-sectional study that measured diarrheal diseases and their etiologic agents. Models were used to estimate burden in data-sparse locations. Diarrhea due to rotavirus infection. Rotavirus-associated mortality and morbidity by country and year and averted deaths attributable to the rotavirus vaccine by country. Rotavirus infection was responsible for an estimated 128 500 deaths (95% uncertainty interval [UI], 104 500-155 600) among children younger than 5 years throughout the world in 2016, with 104 733 deaths occurring in sub-Saharan Africa (95% UI, 83 406-128 842). Rotavirus infection was responsible for more than 258 million episodes of diarrhea among children younger than 5 years in 2016 (95% UI, 193 million to 341 million), an incidence of 0.42 cases per child-year (95% UI, 0.30-0.53). Vaccine use is estimated to have averted more than 28 000 deaths (95% UI, 14 600-46 700) among children younger than 5 years, and expanded use of the rotavirus vaccine, particularly in sub-Saharan Africa, could have prevented approximately 20% of all deaths attributable to diarrhea among children younger than 5 years. Rotavirus-associated mortality has decreased markedly over time in part because of the introduction of the rotavirus vaccine. This study suggests that prioritizing vaccine introduction and interventions to reduce diarrhea-associated morbidity and mortality is necessary in the continued global reduction of rotavirus infection.