Details

Autor(en) / Beteiligte

• Hermenau, Ron
• Ishida, Keishi
• Gama, Sofia
• Hoffmann, Bianca
• Pfeifer-Leeg, Michel
• Plass, Winfried
• Mohr, Jan Frieder
• Wichard, Thomas
• Saluz, Hans-Peter
• Hertweck, Christian

Titel

Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system

Ist Teil von

• Nature chemical biology, 2018-09, Vol.14 (9), p.841-843

Ort / Verlag

United States

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Genome mining and chemical analyses revealed that rhizosphere bacteria (Paraburkholderia graminis) produce a new type of siderophore, gramibactin, a lipodepsipeptide that efficiently binds iron with a logβ value of 27.6. Complexation-induced proton NMR chemical shifts show that the unusual N-nitrosohydroxylamine (diazeniumdiolate) moieties participate in metal binding. Gramibactin biosynthesis genes are conserved in numerous plant-associated bacteria associated with rice, wheat, and maize, which may utilize iron from the complex.