Details

Autor(en) / Beteiligte

• Cantiello, Francesco
• Crocerossa, Fabio
• Russo, Giorgio Ivan
• Gangemi, Vincenzo
• Ferro, Matteo
• Vartolomei, Mihai Dorin
• Lucarelli, Giuseppe
• Mirabelli, Maria
• Scafuro, Chiara
• Ucciero, Giuseppe
• De Cobelli, Ottavio
• Morgia, Giuseppe
• Damiano, Rocco
• Cascini, Giuseppe Lucio

Titel

Comparison Between 64 Cu-PSMA-617 PET/CT and 18 F-Choline PET/CT Imaging in Early Diagnosis of Prostate Cancer Biochemical Recurrence

Ist Teil von

• Clinical genitourinary cancer, 2018-10, Vol.16 (5), p.385

Ort / Verlag

United States

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• To evaluate the diagnostic performance of Cu-PSMA-617 positron emission tomography (PET) with computed tomography (CT) for restaging prostate cancer after biochemical recurrence (BCR) and to compare it with F-choline PET/CT in a per-patient analysis. An observational study was performed of 43 patients with BCR after laparoscopic radical prostatectomy who underwent Cu-PSMA-617 PET/CT and subsequently F-choline PET/CT for restaging. The detection rates (DR) of Cu-PSMA-617 PET/CT and of F-choline PET/CT were calculated by standardized maximum uptake value (SUV ) at 4 hours and SUV at 1 hour as reference, respectively. Furthermore, univariate logistic regression analysis was carried out to identify independent predictive factors of positivity with Cu-PSMA-617 PET/CT. An overall positivity with Cu-PSMA-617 PET/CT was found in 32 patients (74.4%) versus 19 (44.2%) with F-choline PET/CT. Specifically, after stratifying for prostate-specific antigen (PSA) values, we found a good performance of Cu-PSMA-617 PET/CT at low PSA levels compared to F-choline PET/CT, with a DR of 57.1% versus 14.3% for PSA 0.2-0.5 ng/mL (P = .031), and of 60% versus 30% with PSA 0.5-1 ng/mL. At univariate binary logistic regression analysis, PSA level was the only independent predictor of Cu-PSMA-617 PET/CT positivity. No significant difference in terms of DR for both Cu-PSMA-617 PET/CT and F-choline PET/CT was found according to different Gleason score subgroups. In our study cohort, a better performance was observed for Cu-PSMA-617 PET/CT compared to F-choline PET/CT in restaging after BCR, especially in patients with low PSA values.