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Studies on the association of angiotensinogen polymorphisms and hypoxia acclimatization
Ist Teil von
Zhongguo ying yong sheng li xue za zhi, 2016-04, Vol.32 (4), p.314
Ort / Verlag
China
Erscheinungsjahr
2016
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
To research the effects of gene polymorphisms of AGT at G-217A and T174M loci on incidence and the hypoxia acclimation to acute mountain sickness (AMS).
Step 1:61 Han students origin low landers were exposed in acute hypoxia at 4 800 m altitude-equivalent for 6 hours, and took the supine bicycle exercise for 20 min at quantitative load of 60 r/min, 80 W after entering the cabin for 30 min, then the AMS were evaluated by the Lake Louise acute mountain sickness scoring system (LLS). The physical index of heart rate (HR), ambulatory blood pressure and oxygen saturation (SpO
) were measured during exercise. Step 2:The physical index was measured again in acute hypoxic exposure after 3 weeks increasing hypoxia exercise (At an increasing altitude of 2 500 m, 3 500 m, 4 800 m, time of 2 hours/day, 4 days/week, and in moderate intensity of exercise). PCR-RFLP was used to determine the genotypes and alleles frequencies of AGT at G-217A and T174M loci.
In step 1 the hypoxic exposure, for the G-217A locus in AGT, there