Details

Autor(en) / Beteiligte

• Ramis, Ivy B
• Vianna, Júlia S
• Reis, Ana Júlia
• von Groll, Andrea
• Ramos, Daniela F
• Viveiros, Miguel
• da Silva, Pedro E Almeida

Titel

Antimicrobial and Efflux Inhibitor Activity of Usnic Acid Against Mycobacterium abscessus

Ist Teil von

• Planta medica, 2018-11, Vol.84 (17), p.1265-1270

Ort / Verlag

Germany

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• New drugs are needed to treat infections with antimicrobial-resistant ; therefore, we evaluated usnic acid as an antimicrobial agent and efflux inhibitor (EI) against . Usnic acid showed antimicrobial activity, and synergistically, the EI verapamil increased this activity. In addition, when we evaluated the interaction of antimicrobials with usnic acid, the increase of their activity was observed. Finally, usnic acid showed an efflux inhibitory effect between the classical EIs verapamil and carbonyl cyanide m-chlorophenylhydrazine. In conclusion, usnic acid showed both antimicrobial and EI activity, indicating that this natural compound may be a promising scaffold for new drugs against this difficult-to-treat microorganism.