Details

Autor(en) / Beteiligte

• Turilova, A I
• Gan'shina, T S
• Avdyunina, N I
• Pyatin, B M
• Mirzoyan, R S

Titel

ANTIARRHYTHMIC EFFECTS OF 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE HEMISUCCINATE IN COMPARISON TO MEXIDOL.

Ist Teil von

• Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ, 2016, Vol.79 (7), p.8

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Based on the results of experiments on nonlinear white awake male rats it is established that 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate and mexidol exhibit a pronounced antiarrhythmic (antifibrillatory) activity on the calcium chloride arrhythmia model. The maximum effect was observed for hemisuccinate 2-ethyl-6-methyl-3-hydroxypyridine. This substaned; unlike mexidol, also showed high activity on the model of aconitine arrhythmia, which is typical of class I antiarrhytmics. Mexidol did not show this activity. Consequently, 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate possesses a wider therapeutic spectrum than the well-known antiarrhythmic drugs of class I (lidocaine, procainamide) and is comparable in this respect with class IV drug verapamil.