Details

Autor(en) / Beteiligte

• Ratto-Kim, Silvia
• Schuetz, Alexandra
• Sithinamsuwan, Pasiri
• Barber, John
• Hutchings, Nicholas
• Lerdlum, Sukalaya
• Fletcher, James L K
• Phuang-Ngern, Yuwadee
• Chuenarom, Weerawan
• Tipsuk, Somporn
• Pothisri, Mantana
• Jadwattanakul, Tanate
• Jirajariyavej, Supunnee
• Sajjaweerawan, Chayada
• Akapirat, Siriwat
• Chalermchai, Thep
• Suttichom, Duanghathai
• Kaewboon, Boot
• Prueksakaew, Peeriya
• Karnsomlap, Putthachard
• Clifford, David
• Paul, Robert H
• de Souza, Mark S
• Kim, Jerome H
• Ananworanich, Jintanat
• Valcour, Victor

Titel

Characterization of Cellular Immune Responses in Thai Individuals With and Without HIV-Associated Neurocognitive Disorders

Ist Teil von

• AIDS research and human retroviruses, 2018-08, Vol.34 (8), p.685

Ort / Verlag

United States

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• HIV-associated neurocognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating activated/HIV-infected M/M, T cell activation may play a role in the development of HAND. We sought to investigate the relationship between cognition and both CD8 T cell activation (HLA-DR /CD38 ) and HIV-specific CD8 T cell responses at the time of HIV diagnosis and 12 months postinitiation of ART. CD8 T cell activation was increased in HAND compared to cognitive normal (NL) individuals and correlated directly with plasma viral load and inversely with the cognitive status. In addition, Gag-specific cytolytic activity (CD107a/b ) was decreased in HAND compared with NL individuals and correlated with their neurological testing, suggesting a potential role of cytotoxic CD8 T cells in the mechanism of HAND development.