Details

Autor(en) / Beteiligte

• Poddighe, D
• Mathias, C B
• Brambilla, I
• Marseglia, G L
• Oettgen, H C

Titel

Importance of basophils in eosinophilic asthma: the murine counterpart

Ist Teil von

• Journal of biological regulators and homeostatic agents, 2018-03, Vol.32 (2), p.335

Ort / Verlag

Italy

Erscheinungsjahr

2018

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Several experimental studies in mice showed that basophils participate in the initiation of Th2 adaptive immune response, in addition to the effector phase. However, the role of basophils in allergic airway inflammation is less clear. The aim of this experiment was to assess the importance of basophils in recruiting inflammatory cells and, in particular, eosinophils in a murine model of asthma induced by Aspergillus fumigatus allergens. Additionally, bronchial reactivity was evaluated. Basophil depletion resulted in a reduction of inflammatory cells in the airways and eosinophil recruitment was significantly impaired. Also bronchial reactivity seemed to be impaired in basophil-depleted mice, but the result was not statistically significant. According to these preliminary data, basophils seem to influence the local eosinophilic response of allergic asthma.