Details

Autor(en) / Beteiligte

• Reck-Peterson, Samara L
• Redwine, William B
• Vale, Ronald D
• Carter, Andrew P

Titel

The cytoplasmic dynein transport machinery and its many cargoes

Ist Teil von

• Nature reviews. Molecular cell biology, 2018-06, Vol.19 (6), p.382

Ort / Verlag

England

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells. Dynein has critical roles both in interphase and during cell division. Here, we focus on interphase cargoes of dynein, which include membrane-bound organelles, RNAs, protein complexes and viruses. A central challenge in the field is to understand how a single motor can transport such a diverse array of cargoes and how this process is regulated. The molecular basis by which each cargo is linked to dynein and its cofactor dynactin has started to emerge. Of particular importance for this process is a set of coiled-coil proteins - activating adaptors - that both recruit dynein-dynactin to their cargoes and activate dynein motility.