Details

Autor(en) / Beteiligte

• Li, Hao-Ming
• Huang, Ying-Kai
• Su, Yuan-Chih
• Kao, Chia-Hung

Titel

Risk of stroke in patients with dengue fever: a population-based cohort study

Ist Teil von

• Canadian Medical Association journal (CMAJ), 2018-03, Vol.190 (10), p.E285-E290

Ort / Verlag

Canada

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Stroke is a severe neurologic complication of dengue fever, described in only a few case reports. The incidence and risk factors for stroke in patients with dengue remain unclear. We conducted a population-based retrospective cohort study to investigate the risk of stroke in patients with dengue. Using data from the Taiwan National Health Insurance Research Database, we included a total of 13 787 patients with dengue newly diagnosed between 2000 and 2012. The control cohort consisted of patients who did not have dengue, matched 1:1 by demographic characteristics and stroke-related comorbidities. We calculated the cumulative incidences and hazard ratios (HRs) of stroke in both cohorts using Kaplan-Meier curves and Cox proportional hazards regression. The overall incidence rate of stroke was 5.33 per 1000 person-years in the dengue cohort and 3.72 per 1000 person-years in the control cohort, with an adjusted HR of 1.16 (95% confidence interval [CI] 1.01-1.32). The risk of stroke among patients with dengue was highest in the first 2 months after diagnosis (25.53 per 1000 person-years, adjusted HR 2.49, 95% CI 1.48-4.18). Dengue fever was associated with an increased risk of stroke in the first few months after diagnosis. The effect of dengue on stroke may be acute rather than chronic.