Details

Autor(en) / Beteiligte

• Gagelmann, Nico
• Eikema, Diderik-Jan
• Iacobelli, Simona
• Koster, Linda
• Nahi, Hareth
• Stoppa, Anne-Marie
• Masszi, Tamás
• Caillot, Denis
• Lenhoff, Stig
• Udvardy, Miklos
• Crawley, Charles
• Arcese, William
• Mariette, Clara
• Hunter, Ann
• Leleu, Xavier
• Schipperus, Martin
• Delforge, Michel
• Pioltelli, Pietro
• Snowden, John A
• Itälä-Remes, Maija
• Musso, Maurizio
• van Biezen, Anja
• Garderet, Laurent
• Kröger, Nicolaus

Titel

Impact of extramedullary disease in patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation: a study from the Chronic Malignancies Working Party of the EBMT

Ist Teil von

• Haematologica (Roma), 2018-05, Vol.103 (5), p.890

Ort / Verlag

Italy

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• We investigated extramedullary disease in newly diagnosed multiple myeloma patients and its impact on outcome following first-line autologous stem cell transplantation. We identified 3744 adult myeloma patients who received up-front single (n=3391) or tandem transplantation (n=353) between 2005 and 2014 with available data on extramedullary involvement at diagnosis. The overall incidence of extramedullary disease was 18.2% (n=682) and increased per year from 6.5% (2005) to 23.7% (2014). Paraskeletal involvement was found in 543 (14.5%) and extramedullary organ involvement in 139 (3.7%). More patients with extramedullary organ involvement had multiple involved sites (≥2; <0.001). In a comparison of patients with single sites with patients without the disease, up-front transplantation resulted in at least similar 3-year progression-free survival (paraskeletal: =0.86, and extramedullary organ: =0.88). In single paraskeletal involvement, this translated less clearly into worse 3-year overall survival ( =0.07) while single organ involvement was significantly worse ( =0.001). Multiple organ sites were associated with worse outcome ( <0.001 and =0.01). First-line treatment with tandem compared with single transplantation resulted in similar survival in patients with extramedullary disease at diagnosis ( =0.13 for both).