Details

Autor(en) / Beteiligte

• Fountzilas, Christos
• Kaklamani, Virginia G.

Titel

Multi-gene Panel Testing in Breast Cancer Management

Ist Teil von

• Cancer treatment and research, 2018, Vol.173, p.121-140

Ort / Verlag

Switzerland: Springer International Publishing AG

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Hereditary predisposition accounts for approximately 10% of all breast cancers and is mostly associated with germline mutations in high-penetrance genes encoding for proteins participating in DNA repair through homologous recombination (BRCA1 and BRCA2). With the advent of massive parallel next-generation DNA sequencing, simultaneous analysis of multiple genes with a short turnaround time and at a low cost has become possible. The clinical validity and utility of multi-gene panel testing is getting better characterized as more data on the significance of moderate-penetrance genes are collected from large, cancer genetic testing studies. In this chapter, we attempt to provide a general guide for interpretation of panel gene testing in breast cancer and use of the information obtained for clinical decision-making.