Nature structural & molecular biology, 2018-02, Vol.25 (2), p.131-134
2018
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Details
- Autor(en) / Beteiligte
- Titel
- Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp
- Ist Teil von
- Nature structural & molecular biology, 2018-02, Vol.25 (2), p.131-134
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The atomic structure of the infectious, protease-resistant, β-sheet-rich and fibrillar mammalian prion remains unknown. Through the cryo-EM method MicroED, we reveal the sub-ångström-resolution structure of a protofibril formed by a wild-type segment from the β2-α2 loop of the bank vole prion protein. The structure of this protofibril reveals a stabilizing network of hydrogen bonds that link polar zippers within a sheet, producing motifs we have named 'polar clasps'.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1545-9993eISSN: 1545-9985DOI: 10.1038/s41594-017-0018-0Titel-ID: cdi_pubmed_primary_29335561
- Format
- –
- Schlagworte
- Amyloid - chemistry, Amyloidogenic Proteins - chemistry, Animals, Carbamazepine - chemistry, Cattle, Cricetinae, Cryoelectron Microscopy, Deer, Electrons, Humans, Hydrogen Bonding, Mice, Peptides - chemistry, Phylogeny, Prions - chemistry, Protein Structure, Secondary, Proteome, Sheep, Surface Properties, X-Ray Diffraction