Nature reviews. Cancer, 2018-03, Vol.18 (3), p.139-147
2018
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Details
- Autor(en) / Beteiligte
- Titel
- Impact of oncogenic pathways on evasion of antitumour immune responses
- Ist Teil von
- Nature reviews. Cancer, 2018-03, Vol.18 (3), p.139-147
- Ort / Verlag
- England
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Immunotherapeutic interventions are showing effectiveness across a wide range of cancer types, but only a subset of patients shows clinical response to therapy. Responsiveness to checkpoint blockade immunotherapy is favoured by the presence of a local, CD8 T cell-based immune response within the tumour microenvironment. As molecular analyses of tumours containing or lacking a productive CD8 T cell infiltrate are being pursued, increasing evidence is indicating that activation of oncogenic pathways in tumour cells can impair induction or execution of a local antitumour immune response. This Review summarizes our current knowledge of the influence of oncogenic effects on evasion of antitumour immunity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1474-175XeISSN: 1474-1768DOI: 10.1038/nrc.2017.117Titel-ID: cdi_pubmed_primary_29326431
- Format
- –
- Schlagworte
- CD8-Positive T-Lymphocytes - drug effects, Genes, myc - immunology, Humans, Immunotherapy - methods, Lymphocyte Activation, Lymphocytes, Tumor-Infiltrating - immunology, Lymphocytes, Tumor-Infiltrating - pathology, Neoplasms - immunology, Neoplasms - therapy, Oncogenes - immunology, Oncogenes - physiology, Protein-Serine-Threonine Kinases - genetics, Protein-Serine-Threonine Kinases - immunology, Protein-Serine-Threonine Kinases - metabolism, PTEN Phosphohydrolase - genetics, PTEN Phosphohydrolase - immunology, PTEN Phosphohydrolase - metabolism, Tumor Escape, Wnt Signaling Pathway