Details

Autor(en) / Beteiligte

• de Breij, Anna
• Riool, Martijn
• Cordfunke, Robert A
• Malanovic, Nermina
• de Boer, Leonie
• Koning, Roman I
• Ravensbergen, Elisabeth
• Franken, Marnix
• van der Heijde, Tobias
• Boekema, Bouke K
• Kwakman, Paulus H S
• Kamp, Niels
• El Ghalbzouri, Abdelouahab
• Lohner, Karl
• Zaat, Sebastian A J
• Drijfhout, Jan W
• Nibbering, Peter H

Titel

The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms

Ist Teil von

• Science translational medicine, 2018-01, Vol.10 (423)

Ort / Verlag

United States

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Development of novel antimicrobial agents is a top priority in the fight against multidrug-resistant (MDR) and persistent bacteria. We developed a panel of synthetic antimicrobial and antibiofilm peptides (SAAPs) with enhanced antimicrobial activities compared to the parent peptide, human antimicrobial peptide LL-37. Our lead peptide SAAP-148 was more efficient in killing bacteria under physiological conditions in vitro than many known preclinical- and clinical-phase antimicrobial peptides. SAAP-148 killed MDR pathogens without inducing resistance, prevented biofilm formation, and eliminated established biofilms and persister cells. A single 4-hour treatment with hypromellose ointment containing SAAP-148 completely eradicated acute and established, biofilm-associated infections with methicillin-resistant and MDR from wounded ex vivo human skin and murine skin in vivo. Together, these data demonstrate that SAAP-148 is a promising drug candidate in the battle against antibiotic-resistant bacteria that pose a great threat to human health.