Details

Autor(en) / Beteiligte

• Malysheva, Svetlana V.
• Goscinny, Séverine
• Malarvannan, Govindan
• Poma, Giulia
• Andjelkovic, Mirjana
• Voorspoels, Stefan
• Covaci, Adrian
• Van Loco, Joris

Titel

Development and validation of a quantitative UHPLC-MS/MS method for selected brominated flame retardants in food

Ist Teil von

• Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2018-02, Vol.35 (2), p.292-304

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2018

Quelle

Taylor & Francis

Beschreibungen/Notizen

• An ultra-high performance liquid chromatography - tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated (in-house) for the quantification of selected brominated flame retardants (BFRs), including tetrabromobisphenol A (TBBPA), hexabromocyclododecanes (HBCDs), tetrabromobisphenol S (TBBPS) and bromophenols (BPs), in various food matrices. The sample preparation consisted of extraction of TBBPS with acidified acetonitrile followed by a fast dispersive solid-phase extraction (dSPE) clean-up and extraction of the other BFRs with a mixture of hexane and dichloromethane (1:1, v/v) with subsequent clean-up using acidified silica (44%, w/w). The limits of quantification of the method varied widely for the types of food matrices and the different classes of BFRs from 4 pg g −1 wet weight (ww) to 8 ng g −1 ww. For most of the analytes the apparent recovery was in the range 70-120%, and the method precision (under repeatability conditions) was below 20%. The method was successfully applied in proficiency testing exercises as well as for analysis of various food items. Only 25% of the collected food samples contained BFRs, with 4-bromophenol and α-HBCD as the only detected compounds. The contaminated foodstuffs were fish and eggs with concentrations in the range from 48 to 305 pg g −1 ww.